Spyre Therapeutics Inc (SYRE) returns
Spyre Therapeutics returns over 10 years
$1,000 invested in Spyre Therapeutics ten years ago was worth $665.93 at the close on October 30, 2026, with dividends reinvested: an average return of -4.0% a year. The same $1,000 in the S&P 500 (SPY) became $4,166.
Total return by period
| Period | Total return | A year, on average | $1,000 became | S&P 500 (SPY) |
|---|---|---|---|---|
| 1 month | +8.5% | — | $1,085 | -0.9% |
| 3 months | -4.9% | — | $951.33 | +2.1% |
| Year to date | +194.7% | — | $2,947 | +11.7% |
| 1 year | +298.0% | — | $3,980 | +12.4% |
| 3 years | +726.7% | +102.2% | $8,267 | +88.5% |
| 5 years | -47.2% | -12.0% | $527.65 | +76.0% |
| 10 years | -33.4% | -4.0% | $665.93 | +316.6% |
Spyre Therapeutics return by calendar year
| Year | SYRE | S&P 500 (SPY) | Difference |
|---|---|---|---|
| 2026 to date | +194.7% | +11.7% | +183.1% |
| 2025 | +40.7% | +17.7% | +23.0% |
| 2024 | +8.2% | +24.9% | -16.7% |
| 2023 | +91.3% | +26.2% | +65.1% |
| 2022 | -90.5% | -18.2% | -72.4% |
| 2021 | -39.6% | +28.7% | -68.4% |
| 2020 | +3.0% | +18.4% | -15.4% |
| 2019 | +2.0% | +31.2% | -29.2% |
| 2018 | +38.4% | -4.6% | +43.0% |
| 2017 | +24.4% | +21.7% | +2.7% |
Past returns do not predict future returns. Returns are computed from our daily closes, adjusted for splits and with dividends reinvested on their ex-dates; taxes and trading costs are left out.
See also: SYRE financials
No forecast, no recommendation. This page describes Spyre Therapeutics Inc from published data; it is not advice to buy, sell or hold any security.
Figures as of the close on Oct 30, 2026 unless a row says otherwise. Prices are split adjusted; returns include dividends reinvested. Data may be delayed. See the disclaimer and how TrendArc works.