Upstream Bio Inc (UPB) returns
$3.41 +4.28% Close Oct 30, 2026 Live
Upstream Bio returns over 1 year
$1,000 invested in Upstream Bio one year ago was worth $132.32 at the close on October 30, 2026, with dividends reinvested. The same $1,000 in the S&P 500 (SPY) became $1,124.
UPB, $10,000 investedS&P 500 (SPY)
$2,000$5,000$10,000
20252026
Total return by period
| Period | Total return | A year, on average | $1,000 became | S&P 500 (SPY) |
|---|---|---|---|---|
| 1 month | -35.3% | — | $647.06 | -0.9% |
| 3 months | -48.1% | — | $519.03 | +2.1% |
| Year to date | -87.4% | — | $125.60 | +11.7% |
| 1 year | -86.8% | — | $132.32 | +12.4% |
Upstream Bio return by calendar year
| Year | UPB | S&P 500 (SPY) | Difference |
|---|---|---|---|
| 2026 to date | -87.4% | +11.7% | -99.1% |
| 2025 | +65.1% | +17.7% | +47.4% |
Past returns do not predict future returns. Returns are computed from our daily closes, adjusted for splits and with dividends reinvested on their ex-dates; taxes and trading costs are left out.
See also: UPB financials
No forecast, no recommendation. This page describes Upstream Bio Inc from published data; it is not advice to buy, sell or hold any security.
Figures as of the close on Oct 30, 2026 unless a row says otherwise. Prices are split adjusted; returns include dividends reinvested. Data may be delayed. See the disclaimer and how TrendArc works.