Prime Medicine Inc (PRME) returns
Prime Medicine returns over 3 years
$1,000 invested in Prime Medicine three years ago was worth $811.00 at the close on October 30, 2026, with dividends reinvested: an average return of -6.7% a year. The same $1,000 in the S&P 500 (SPY) became $1,885.
Total return by period
| Period | Total return | A year, on average | $1,000 became | S&P 500 (SPY) |
|---|---|---|---|---|
| 1 month | +54.5% | — | $1,545 | -0.9% |
| 3 months | +56.3% | — | $1,563 | +2.1% |
| Year to date | +36.0% | — | $1,360 | +11.7% |
| 1 year | +8.5% | — | $1,085 | +12.4% |
| 3 years | -18.9% | -6.7% | $811.00 | +88.5% |
Prime Medicine return by calendar year
| Year | PRME | S&P 500 (SPY) | Difference |
|---|---|---|---|
| 2026 to date | +36.0% | +11.7% | +24.3% |
| 2025 | +18.8% | +17.7% | +1.1% |
| 2024 | -67.0% | +24.9% | -91.9% |
| 2023 | -52.3% | +26.2% | -78.5% |
Past returns do not predict future returns. Returns are computed from our daily closes, adjusted for splits and with dividends reinvested on their ex-dates; taxes and trading costs are left out.
See also: PRME financials
No forecast, no recommendation. This page describes Prime Medicine Inc from published data; it is not advice to buy, sell or hold any security.
Figures as of the close on Oct 30, 2026 unless a row says otherwise. Prices are split adjusted; returns include dividends reinvested. Data may be delayed. See the disclaimer and how TrendArc works.