Denali Therapeutics Inc (DNLI) returns
Denali Therapeutics returns over 5 years
$1,000 invested in Denali Therapeutics five years ago was worth $391.73 at the close on October 30, 2026, with dividends reinvested: an average return of -17.1% a year. The same $1,000 in the S&P 500 (SPY) became $1,760.
Total return by period
| Period | Total return | A year, on average | $1,000 became | S&P 500 (SPY) |
|---|---|---|---|---|
| 1 month | -8.4% | — | $916.30 | -0.9% |
| 3 months | -22.2% | — | $777.82 | +2.1% |
| Year to date | +14.7% | — | $1,147 | +11.7% |
| 1 year | +15.6% | — | $1,156 | +12.4% |
| 3 years | +2.9% | +1.0% | $1,029 | +88.5% |
| 5 years | -60.8% | -17.1% | $391.73 | +76.0% |
Denali Therapeutics return by calendar year
| Year | DNLI | S&P 500 (SPY) | Difference |
|---|---|---|---|
| 2026 to date | +14.7% | +11.7% | +3.0% |
| 2025 | -19.0% | +17.7% | -36.7% |
| 2024 | -5.0% | +24.9% | -29.9% |
| 2023 | -22.8% | +26.2% | -49.0% |
| 2022 | -37.6% | -18.2% | -19.5% |
| 2021 | -46.8% | +28.7% | -75.5% |
| 2020 | +380.8% | +18.4% | +362.5% |
| 2019 | -15.7% | +31.2% | -46.9% |
| 2018 | +32.1% | -4.6% | +36.7% |
Past returns do not predict future returns. Returns are computed from our daily closes, adjusted for splits and with dividends reinvested on their ex-dates; taxes and trading costs are left out.
See also: DNLI financials
No forecast, no recommendation. This page describes Denali Therapeutics Inc from published data; it is not advice to buy, sell or hold any security.
Figures as of the close on Oct 30, 2026 unless a row says otherwise. Prices are split adjusted; returns include dividends reinvested. Data may be delayed. See the disclaimer and how TrendArc works.